Subsequent to Helen's remarriage to another United States Air Force serviceman, Vanessa and her brother moved to Turkey with their mother and stepfather. By 1990, as a result of Desert Shield, Minnillo and her brother returned to their father's home, eventually settling in Charleston, South Carolina where she attended Bishop England High School and was a cheerleader. Vanessa was raised from then on by her father and his second wife Donna.
Minnillo entered the public eye as Miss South Carolina Teen USA 1998, and went on to be crowned as the winner of the 1998 Miss Teen USA pageant.